Publications

Physiology

• The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure.

  Packer M. J Am Coll Cardiol. 1992;20:24 8 –254.

• Cardiac vagal activity: a target for intervention in heart disease.

  Townend JN, Littler WA. Lancet. 1995;345:937–938.

• Muscarinic Modulation of the Sodium-Calcium Exchanger in Heart Failure

  Hanlon, Eric Elgin, Dan H. Schulze and Mark C.P. Haigney Shao-kui Wei, Abdul M. Ruknudin, Matie Shou, John M. McCurley, Stephen U. Circulation 2007;115;1225-1233; originally published online Mar 5, 2007.

• Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy.

  Olshansky B, Sabbah HN, Hauptman PJ, Colucci WS Circulation 2008 Aug 19;118(8):863-71

• Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced canine model of ventricular failure.

  Binkley PF, Nunziata E, Haas GJ, Nelson SD, Cody RJ. J Am Coll Cardiol. 1991;18:464–472.

• Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction

  Vanoli E, De Ferrari GM, Stramba-Badiale M, Hull SS Jr, Foreman RD, Schwartz PJ.  Circ Res. 1991;68:1471–1481.

• Role of nitric oxide in parasympathetic modulation of beta adrenergic myocardial contractility in normal dogs.

  Hare JM, Keaney JF Jr, Balligand JL, Loscalzo J, Smith TW, Colucci WS.  J Clin Invest. 1995; 95:360 –366.

• Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation.

  Keaney JF Jr, Hare JM, Balligand JL, Loscalzo J, Smith TW, Colucci WS.  Am J Physiol. 1996;271: H2646–H2652.

• Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications.

  Mortara A, La Rovere MT, Pinna GD, et al.  Circulation 1997;96:3450–8.

• Prevention of diminished parasympathetic control of the heart in experimental heart failure.

  Bibevski S, Dunlap ME.  Am J Physiol Heart Circ Physiol 2004;287:H1780–5.

• Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats.

  Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K. Circulation 2004;109:120–4.

• Vagal stimulation markedly suppresses arrhythmias in conscious rats with chronic heart failure after myocardial infarction.

  Zheng C, Li M, Inagaki M, Kawada T, Sunagawa K, Sugimachi M.  Conf Proc IEEE

• Long-term therapy with neuroselective electric vagus nerve stimulation improves LV function and attenuates global LV remodelling in dogs with chronic heart failure.

  Sabbah HN, Rastogi S, Mishra S, Gupta RC, Ilsar I, Imai M, Cohen U, Ben-David T, Ben-Ezra O.  Eur J Heart Fail Suppl. 2005;4:166. Abstract.

• Autonomic imbalance and immune activation in chronic heart failure — Pathophysiological links

  Ewa A. Jankowska , Piotr Ponikowski, Massimo F. Piepoli, Waldemar Banasiak, Stefan D. Anker, Philip A. Poole-Wilson.  Cardiovascular Research 70 (2006) 434 – 445  

Physiology Background:
Published in Heart Failure Reviews, March 2011

• Sympathetic-Parasympathetic Interaction in Health and Disease: Abnormalities and Relevance in Heart Failure

  Peter J. Schwartz, MD, Gaetano M De Ferrari, MD

• Arrhythmias and Vagus Nerve Stimulation

  Youhua Zhang, MD, PhD, Todor Mazgalev, MD

• Methods of Assessing Vagus Nerve Activity and Reflexes

  Mark W. Chapleau, PhD, Rasna Sabharwal, PhD

• Evidence for Impaired Vagus Nerve Activity in Heart Failure

  Steve Bibebvski, MD, PhD, Mark Dunlap, MD

• Inflammatory Cytokines and Nitric Oxide in Heart Failure and Potential Modulation by Vagus Nerve Stimulation

  Weiwei Li, MD, Brian Olshansky, MD

• Histopathology of the Stimulated Vagus Nerve: Primum non nocere

  ML Cohen, MD, Zhanna Georgievskaya

• Vagus Nerve Stimulation in Experimental Heart Failure

  Hani N. Sabbah • Itamar Ilsar • Asaph Zaretsky •Sharad Rastogi • Mengjun Wang • Ramesh C. Gupta

• Pharmacologic Modulation of Parasympathetic Activity in Heart Failure

  Monali Desai, MD, Mari Watanabe, PhD, MD, Abhay Laddu, MD, Paul J. Hauptman, MD

• Vagus Nerve Stimulation: From Pre-Clinical to Clinical Application: Challenges and Future

  Gaetano M. De Ferrari, MD, Peter J. Schwartz, MD

Clinical

• Long term vagal stimulation in patients with advanced heart failure: first experience in man.

  Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, Raineri C, Campana C, Revera M, Ajmone-Marsan N, Tavazzi L, Odero A. Eur J Heart Fail. 2008 Sep;10(9):884-91

• Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure.

  De Ferrari GM, Crijns HJ, Borggrefe M, Milasinovic G, Smid J, Zabel M, Gavazzi A, Sanzo A, Dennert R, Kuschyk J, Raspopovic S, Klein H, Swedberg K, Schwartz PJ; for the CardioFit Multicenter Trial Investigators Eur Heart J. Published online October 28, 2010

• Vagus stimulation: Mechanisms and current clinical importance in heart failure.

  Kuschyk J, Borggrefe M. Herzschrittmacherther Elektrophysiol. Published on line, March 7, 2011